TLR7/8 agonist 8 (compound 24m) is a potent dual agonist for toll-like receptors 7 and 8 (TLR7/8), exhibiting half-maximal effective concentrations (EC50s) of 27 nM for human TLR7 (hTLR7) and 12 nM for human TLR8 (hTLR8). This compound enhances the efficacy of PD-1/PD-L1 inhibitors in antitumor activity [1].
Molekulargewicht:
418.53
CAS Nummer:
[2649170-16-9]
Formel:
C24H30N6O
Target-Kategorie:
Others|||TLR
T79068
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