BVFP is a PGRN-SORT1 inhibitor/SORT1 antagonist that binds to key residues 588-593 of PGRN, a multifunctional secreted glycoprotein, and SORT1, a neuronal receptor for PGRN.BVFP is able to block PGRN-SORT1 binding, restore extracellular levels of PGRN , inhibits SORT1-mediated rPGRN endocytosis, and has therapeutic potential for frontotemporal lobe dementia (FTLD-TDP).
Molekulargewicht:
345.12
Reinheit:
98.74%
CAS Nummer:
[357158-20-4]
Formel:
C13H8BrF3N2O
Target-Kategorie:
Neurotensin Receptor
T79105
T79105
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