GBD-9, a dual-mechanism degrader, effectively promotes the degradation of BTK and GSPT1 through recruitment of E3 ligase cereblon (CRBN). As a PROTAC molecule, GBD-9 induces BTK degradation, while also acting as a molecular glue for GSPT1 degradation, demonstrating potent inhibition of cancer cell growth [1].
Molekulargewicht:
797.9
CAS Nummer:
[2864408-92-2]
Formel:
C44H47N9O6
Target-Kategorie:
BTK|||PROTACs|||Molecular Glues
T79139
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