Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 µM for XO inhibition. It effectively impedes uric acid uptake in HEK293 cells with URAT1 expression, evidenced by a Ki of 0.145 µM. In hyperuricemic mice models, the compound has been shown to reduce serum urate levels and uric acid excretion, indicating potential utility for hyperuricemia research [1].
Molekulargewicht:
322.15
CAS Nummer:
[1239488-96-0]
Formel:
C14H12BrNO3
Target-Kategorie:
Xanthine Oxidase|||OAT
T79177
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