BLT2 antagonist-1 (compound 15b) is a selective inhibitor of the BLT2 receptor, impeding the chemotaxis of CHO-BLT2 cells at an IC50 of 224 nM without affecting CHO-BLT1 cell chemotaxis. It blocks the interaction between LTB4 and the BLT2 receptor with a K_i of 132 nM and may serve as a research tool for inflammatory airway diseases, including asthma and chronic obstructive pulmonary disease [1].
Molekulargewicht:
435.49
CAS Nummer:
[2069220-61-5]
Formel:
C26H26FNO4
Target-Kategorie:
Leukotriene Receptor
T79418
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