Leucettinib-92 is a small-molecule inhibitor of the DYRK and CLK kinase families that exhibits differential inhibitory activity across multiple kinases, with IC50 values of 147 nM for CLK1, 39 nM for CLK2, 5.2 nM for CLK4, 0.8 µM for CLK3, 124 nM for DYRK1A, 204 nM for DYRK1B, 0.16 µM for DYRK2, 1.0 µM for DYRK3, 0.52 µM for DYRK4, and 2.78 µM for GSK3, supporting its use in kinase signaling and regulatory mechanism research.
Molekulargewicht:
378.49
CAS Nummer:
[2732859-57-1]
Formel:
C21H22N4OS
Target-Kategorie:
DYRK|||CDK|||GSK-3
T79562
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