STAT3-IN-20 (Compound 40), with an IC50 of 0.65 µM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear translocation, and subsequent gene transcription. The compound demonstrates antiproliferative effects on DU145 and MDA-MB-231 cancer cell lines, which have overactivated STAT3, with IC50 values of 2.97 µM and 3.26 µM, respectively. Moreover, STAT3-IN-20 induces cell cycle arrest and apoptosis [1].
Molekulargewicht:
593.64
CAS Nummer:
[2768427-54-7]
Formel:
C30H27F4N7S
Target-Kategorie:
STAT
T79662
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