PI3Kalpha/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kalpha and HDAC6, with IC50 values of 2.9 nM and 26 nM, respectively. It hinders AKT(Ser473) phosphorylation and promotes the accumulation of acetylated alpha-tubulin without affecting acetylated histones H3 and H4. The compound exhibits potent anti-cancer efficacy, inhibiting the L-363 cell line with an IC50 of 0.17 µM [1].
Molekulargewicht:
669.7
Formel:
C27H30F3N7O6S2
Target-Kategorie:
PI3K|||HDAC
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