VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1alpha and enhances its transcriptional activity. It shows promise for applications as a HIF-1alpha stabilizer and for the degradation of proteolytically targeted chimeras (PROTACs) [1].
Molekulargewicht:
544.68
Formel:
C28H37FN4O4S
Target-Kategorie:
Ligands for E3 Ligase|||HIF/HIF Prolyl-Hydroxylase
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
