DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth. This compound effectively suppresses methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 with an IC50 of 15.6 ng/mL in mouse models of systemic and thigh infections [1].
Molekulargewicht:
346.41
Formel:
C18H14N6S
Target-Kategorie:
Others|||DHFR|||Antibacterial
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
