CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, inhibits CYP51 (IC50: 0.884 µM) and PD-L1 (IC50: 0.083 µM), induces early apoptosis in the fungal cell cycle, decreases intracellular IL-2, NLRP3, and NF-kappaBp65 protein levels, causes mitochondrial damage and ROS accumulation, leading to fungal lysis and cell death [1].
