CYP51/PD-L1-IN-2 (compound L20), a quinazoline with antifungal properties, is a potent dual inhibitor targeting both CYP51 (IC50: 0.263 µM) and PD-L1 (IC50: 0.017 µM). The compound promotes early apoptosis in the fungal cell cycle, diminishes intracellular proteins IL-2, NLRP3, and NF-kappaBp65, causes mitochondrial damage and ROS build-up, leading to fungal cell lysis and death [1].
