SMD-3040 is a potent and selective SMARCA2 PROTAC degrader that achieves efficient target protein elimination with a DC50 of 12 nM and a Dmax of 91%, leading to robust inhibition of tumor cell proliferation and pronounced antitumor activity, and is enabled by rational assembly of a SMARCA2/4 ligand and a VHL ligand, supporting its application in melanoma and broader oncology research.
Molekulargewicht:
943.21
CAS Nummer:
[3033109-92-8]
Formel:
C52H66N10O5S
Target-Kategorie:
Epigenetic Reader Domain|||PROTACs
T79820
T79820
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