UNC3474, a small molecule ligand, selectively interacts with the aromatic methyl-lysine binding cage of the tumor protein 53BP1 Tudor domain (TT), exhibiting a dissociation constant (Kd) of 1.00.3 µM. It impedes 53BP1s recruitment to DNA double-strand breaks (DSBs), maintaining the proteins autoinhibited state within cells [1].
Molekulargewicht:
276.42
CAS Nummer:
[1648707-79-2]
Formel:
C17H28N2O
Target-Kategorie:
MDM-2/p53|||Others
T80899
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