Tri-GalNAc-NHS ester is a high-affinity triantennary N-acetylgalactosamine (GalNAc) derivative acting as a specific ligand for the Asialoglycoprotein Receptor (ASGPR) with a Kd of approximately 2.5 nM, which conjugates to antibodies via the NHS ester moiety to construct Lysosome Targeting Chimeras (LYTACs) for the liver-specific degradation of extracellular proteins.
Molekulargewicht:
1833.01
CAS Nummer:
[1953146-83-2]
Formel:
C79H137N11O37
Target-Kategorie:
LYTACs
T80946
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