PI3Kalpha-IN-14 (compound F8), a potent PI3Kalpha inhibitor, exhibits an IC50 value of 0.14 nM and significantly reduces mitochondrial membrane potential, leading to G1 phase cell cycle arrest and apoptosis in U87-MG cells. It also shows substantial antiproliferative effects against various tumor cell lines, including PC-3 (IC50 of 0.28 µM), HCT-116 (IC50 of 0.57 µM), and U87-MG (IC50 of 1.37 µM) [1].
Target-Kategorie:
PI3K|||Apoptosis
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