Tat-betasyn-degron, an alpha-synuclein knockdown peptide, integrates three domains: the HIV-1 Tat plasma membrane transduction domain, an alpha-synuclein binding domain (betasyn) representing amino acids 36-45 of beta-synuclein, and a proteasomal targeting domain (degron). It effectively binds to recombinant alpha-synuclein, demonstrating a significant reduction in alpha-synuclein levels in primary rat cortical neuron cultures.
Molekulargewicht:
3146.67
Formel:
C132H237N59O31.XCF3COOH
T83726
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten