NCI 126224, CAS [[65974-52-9]]

Produktübersicht

• Artikelname: NCI 126224, CAS [[65974-52-9]]
• Artikelnummer: TGM-T83895
• Hersteller Artikelnummer: T83895
• Alternativnummer: TGM-T83895-1MLX10MM(INDMSO),TGM-T83895-1MG,TGM-T83895-5MG,TGM-T83895-10MG,TGM-T83895-25MG,TGM-T83895-50MG,TGM-T83895-100MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: NCI126224 , NCI-126224

Produktbeschreibung

NCI 126224 is a Toll-like receptor 4 (TLR4) antagonist that selectively inhibits nitric oxide production induced by the TLR4 agonist LPS in RAW 264.7 macrophages (IC50 = 0.31 µM), while exhibiting weaker effects against the TLR7/8 agonist R-848, TLR1/2 agonist Pam3CSK4, and TLR3 agonist poly(I:C). NCI 126224 also inhibits FSL-1-induced NO production at 0.6 µM and suppresses LPS-induced NF-kappaB activity in BV-2 glial cells, while reducing IL-1beta and TNF-alpha levels in RAW 264.7 cells (IC50s of 5.92 and 1.54 µM, respectively). 0.42, and 1.54 µM, respectively), demonstrating its significant value in studies of inflammatory and innate immune signaling pathways.

Produkteigenschaften

• Molekulargewicht: 265.2
• Reinheit: 99.95%
• CAS Nummer: [65974-52-9]
• Formel: C12H11NO6
• Target-Kategorie: TLR

Bilder

T83895