N-didesmethyl Loperamide, an active metabolite of the peripheral µ1-opioid receptor agonist loperamide, impedes electrically induced contractions in isolated guinea pig myenteric plexus (IC50 = 370 nM) and enhances the sensitivity of a chloroquine-resistant P. falciparum strain to chloroquine (EC50 = 482 nM). Notably, it achieves this without causing toxicity in A-10 vascular smooth muscle cells (IC50 = >10,000 nM).
Molekulargewicht:
448.98
CAS Nummer:
[66164-06-5]
Formel:
C27H29ClN2O2
Target-Kategorie:
Others|||Drug Metabolite
T83899
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