eIF4A i28, an inhibitor of the eukaryotic initiation factor-4A (eIF4A) with an IC50 of 8.60 µM in an eIF4A ATPase assay, effectively reduces the viability of BJAB Burkitt lymphoma cells, as indicated by an EC50 of 0.46 µM in a CellTiter-Glo (CTG) luminescence cell viability assay. This compound functions as an RNA-competitive, ATP-uncompetitive eIF4A inhibitor.
Molekulargewicht:
416.43
CAS Nummer:
[2861994-92-3]
Formel:
C24H20N2O5
Target-Kategorie:
Others
T83935
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