CELT-133 is a selective fluorescent antagonist for the halpha1A adrenergic receptor, demonstrating complete selectivity towards alpha1A over alpha2A receptors, with a Ki of 5 nM and 15% displacement at 1 µM in radioligand binding assays, respectively. It displays equivalent affinity across all alpha1 adrenergic receptor subtypes. Notably, CELT-133 features excitation and emission maxima (lambda) at 560 and 571 nm, respectively, making it suitable for use as an acceptor dye in time-resolved Förster resonance energy transfer (TR-FRET) assays when paired with the CoraFluor 1 TR-FRET donor.
Molekulargewicht:
1318.43
Target-Kategorie:
Others
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