(S)-Sabutoclax, CAS [[1228178-73-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: (S)-Sabutoclax, CAS [[1228178-73-1]] Preis auf Anfrage
• Artikelnummer: TGM-T84686
• Hersteller Artikelnummer: T84686
• Alternativnummer: TGM-T84686-10MG,TGM-T84686-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: (S)-BI-97C1

Produktbeschreibung

(S)-Sabutoclax ((S)-BI-97C1), an optically pure derivative of apogossypol, serves as a pan-active inhibitor of the antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. It effectively blocks the binding of BH3 peptides to key proteins in the family, including Bcl-XL, Bcl-2, Mcl-1, and Bfl-1, displaying inhibitory concentration (IC50) values of 0.31, 0.32, 0.20, and 0.62 µM, respectively. Furthermore, (S)-Sabutoclax demonstrates potent efficacy in inhibiting the growth of various cancer cell lines, such as those from human prostate cancer, lung cancer, and lymphoma, with half-maximal effective concentration (EC50) values of 0.13, 0.56, and 0.049 µM, respectively. This compound is utilized in research focusing on apoptosis-based cancer therapies [1].

Produkteigenschaften

• Molekulargewicht: 732.84
• CAS Nummer: [1228178-73-1]
• Formel: C42H42N2O8S
• Target-Kategorie: Others|||Bcl-2 Family

Bilder

T84686

T84686