PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.
Molekulargewicht:
376.79
CAS Nummer:
[1989620-03-2]
Formel:
C17H17ClN4O4
Target-Kategorie:
Others|||Histone Methyltransferase
T84861
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