5alpha-Androstan-3beta-ol, a steroidal androgen, demonstrates selective interaction with cellular components, showing affinity for the androgen receptor (AR) with an IC50 of 1.7 µM and activating the pregnane X receptor (PXR) in HepG2 cells with an EC50 of 0.8 µM. It selectively inhibits the hydroxylase activities of 16alpha- and 6beta-hydroxylase over 16beta- or 7alpha-hydroxylase, with IC50 values of 70 and 110 µM, compared to >150 µM for the latter enzymes, indicating a specificity in its enzyme inhibition profile. Additionally, administration of this compound at a dosage of 30 mg/kg results in a decrease in testis weight and sperm production in mice, highlighting its biological effects on male reproductive parameters.
Molekulargewicht:
276.46
CAS Nummer:
[1224-92-6]
Formel:
C19H32O
Target-Kategorie:
Endogenous Metabolite|||Others
T84963
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