LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 µM. The topical administration of LX7101 (3 µl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.
Molekulargewicht:
488
CAS Nummer:
[2319882-48-7]
Formel:
C23H29N7O3?HCl
Target-Kategorie:
Others|||LIM Kinase|||ROCK|||PKA
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