AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 µM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 µM and 1.342 µM, respectively. AChE-IN-63 is effective in inhibiting Abeta aggregation and preventing the formation and deposition of Abeta1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimers disease [1].
