ATF4-IN-1 (Compound 21) serves as an inhibitor of ATF4, demonstrating effective suppression of ATF4 expression in Thapsigargin-stimulated HEK-293T cells with an IC50 of 32.43 nM. Compared to ISRIB, ATF4-IN-1 shows enhanced activity and exhibits minimal cytotoxicity, with an IC50 of 96 µM in HEK-293T cells. This compound is utilized in the investigation of neurodegenerative diseases [1].
Molekulargewicht:
486.35
CAS Nummer:
[2991057-76-0]
Formel:
C24H21Cl2N3O4
Target-Kategorie:
Others|||PERK
T85739
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