BET-IN-20 (compound 10), a BRD4 BD1 inhibitor (IC 50 =1.9 nM), exhibits significant anticancer properties. It promotes apoptosis in acute myeloid leukemia (AML) cells and arrests the cell cycle in the G0/G1 phase. Additionally, BET-IN-20 inhibits both c-Myc and CDK6, and enhances PARP cleavage [1].
Molekulargewicht:
412.48
CAS Nummer:
[1300735-76-5]
Formel:
C25H24N4O2
Target-Kategorie:
Epigenetic Reader Domain|||Apoptosis
T85846
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