GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].
Molekulargewicht:
344.37
CAS Nummer:
[886599-05-9]
Formel:
C19H16N6O
Target-Kategorie:
Others|||Aurora Kinase
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