HDAC6-IN-33 (compound 6), an irreversible and selective HDAC6 inhibitor, demonstrates a potency with an IC 50 of 193 nM and lacks activity against HDAC1-4. This compound adheres to HDAC6 through a two-step slow-binding mechanism, establishing it as a tight-binding inhibitor [1].
Molekulargewicht:
303.27
CAS Nummer:
[2444302-23-0]
Formel:
C14H11F2N5O
Target-Kategorie:
HDAC
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