Calderasib (MK-1084) is a selective KRAS G12C inhibitor with an IC50 value of 1.2 nM . Calderasib (MK-1084) exhibits significant anticancer activity, and it can be employed either as a monotherapy or in combination with the PD-1 inhibitor Pembrolizumab, providing a versatile approach for the investigation of KRAS-mutant driven cancers.
Molekulargewicht:
637.08
Reinheit:
98.69%
CAS Nummer:
[2641216-67-1]
Formel:
C32H31ClF2N6O4
Target-Kategorie:
Ras|||Kras
T86905
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