PP487 is a dual tyrosine kinase/PI(3)K inhibitor, exhibiting IC50 values of 0.017 µM, 0.072 µM, 0.004 µM, 0.01 µM, 0.55 µM, 0.22 µM, and < 0.01 µM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. It is applicable in cancer research [1].