SIK-IN-2 (Compound 45) is a potent inhibitor of salt-inducible kinase (SIK), effectively targeting SIK1, SIK2, and SIK3 with IC50 values of 0.1, 0.2, and 0.4 nM, respectively. Additionally, it suppresses TNFa release with an IC50 of 0.5 nM and promotes LPS-induced IL-10 release with an EC50 of 2 nM in human macrophages [1].
Molekulargewicht:
418.52
CAS Nummer:
[3033846-20-4]
Formel:
C22H22N6OS
Target-Kategorie:
AMPK
T87394
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