TEAD-IN-11 (compound 38) exhibits potent inhibitory activity against TEAD1 (IC 50 = 8.7 nM), TEAD2 (IC 50 = 3.4 nM), and TEAD3 (IC 50 = 5.6 nM), demonstrating selectivity for these isoforms as a covalent inhibitor. This compound is valuable for cancer research.
Molekulargewicht:
293.28
CAS Nummer:
[3032196-88-3]
Formel:
C16H14F3NO
Target-Kategorie:
YAP
T87984
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