BC-1901S functions as a proteasome-independent activator and stabilizer of NRF2. By binding to DCAF1 (E3 ligase subunit), it disrupts the NRF2/DCAF1 interaction and activates NRF2 through the inhibition of NRF2 ubiquitination, independent of KEAP1. BC-1901S has demonstrated anti-inflammatory effects in a murine model of LPS-induced acute lung injury.
Molekulargewicht:
424.9
CAS Nummer:
[1358617-36-3]
Formel:
C23H22ClFN4O
Target-Kategorie:
E1/E2/E3 Enzyme|||Nrf2
T87995
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