DLC-50 is a dual inhibitor of PARP-1 and HDAC-1, exhibiting IC50 values of 1.2 nM and 31 nM respectively. It hinders the proliferation of cancer cells such as MDA-MB-436, MDA-MB-231, and MCF-7 with IC50 values of 0.3 µM, 2.7 µM, and 2.41 µM respectively. Additionally, DLC-50 induces apoptosis in MDA-MB-231 cells and causes cell cycle arrest at the G2 phase.
Molekulargewicht:
585.71
CAS Nummer:
[2928537-98-6]
Formel:
C28H32FN5O4S2
Target-Kategorie:
HDAC|||Apoptosis|||PARP
T88516
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