GSK-3beta Inhibitor 17 (compound 5 n) reduces the expression of p-p65 and KIM-1 proteins in a dose-dependent manner (16, 32, 64 µM) induced by cisplatin. Additionally, at a concentration of 32 µM, it decreases the levels of TNF-alpha, IL-1beta, IL-6, and MCP-1 mRNA in an acute kidney injury (AKI) model of HK-2 cells triggered by cisplatin.
Molekulargewicht:
617.58
CAS Nummer:
[2521624-67-7]
Formel:
C26H18F3N5O6S2
Target-Kategorie:
GSK-3
T88524
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