BPR5K230 is a dual inhibitor of the receptor tyrosine kinases MER and AXL, exhibiting IC50 values of 4.1 nM and 9.2 nM, respectively. It inhibits the proliferation of Ba/F3-MER cells with an IC50 of 5 nM. BPR5K230 demonstrates favorable pharmacokinetics in mice and displays anti-inflammatory and antitumor effects in mouse models against 4T1, MDA-MB-231, MC38, and Hepa1-6.
Molekulargewicht:
655.68
CAS Nummer:
[3029897-97-7]
Formel:
C37H30FN7O4
Target-Kategorie:
TAM Receptor
T88671
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