EPHA2/A4/GAK-IN-1 (compound 55) is a potent inhibitor of EPHA2, EPHA4, and GAK, exhibiting KD values of 180.5 nM for EPHA2 and 19.2 nM for GAK, respectively. The predicted half-life of EPHA2/A4/GAK-IN-1 in microsomal stability tests measures 4.6 hours. Additionally, this compound has antiviral efficacy, capable of preventing Dengue virus infection in Huh7 hepatocytes.
