AF3485, a human mPGES-1 inhibitor, exhibits anti-tumor activity both in vitro and in vivo. It achieves this by reducing PGE2 production, inhibiting EGFR signaling, and decreasing the expression of VEGF and FGF-2, which suppresses tumor-associated angiogenesis. When subchronically administered to mice with human A431 xenograft tumors, AF3485 effectively curtails tumor growth.
Molekulargewicht:
398.38
CAS Nummer:
[1195786-61-8]
Formel:
C22H17F3N2O2
T88956
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
