hDHODH-IN-15 (Compound H19) acts as an inhibitor of human dihydroorotate dehydrogenase (hDHODH), demonstrating an IC50 of 0.21 µM. It exhibits cytotoxic effects in cancer cells such as NCI-H226, HCT-116, and MDA-MB-231, with IC50 values ranging from 0.95 to 2.81 µM. Furthermore, hDHODH-IN-15 induces ferroptosis in HCT-116 cells and shows antitumor activity.
Target-Kategorie:
Ferroptosis|||Dehydrogenase
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