PBE-AMF is a prodrug that activates H2O2 and exhibits anticancer activity. It impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing cell death (apoptosis), and blocking the cell cycle. PBE-AMF effectively and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 µM) while sparing non-cancerous MCF-10A cells.
Target-Kategorie:
DNA/RNA Synthesis|||Apoptosis|||Reactive Oxygen Species
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