Icotrokinra, CAS [[2763602-16-8]]

Produktübersicht

• Artikelname: Icotrokinra, CAS [[2763602-16-8]]
• Artikelnummer: TGM-T89073
• Hersteller Artikelnummer: T89073
• Alternativnummer: TGM-T89073-1MG,TGM-T89073-10MG,TGM-T89073-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: JNJ2113 , JNJ-2113 , JNJ-77242113 , PN-235 , JNJ77242113 , PN235

Produktbeschreibung

Icotrokinra is an orally bioavailable and highly selective antagonist of the interleukin-23 receptor (IL-23R), thereby interfering with IL-23-mediated signaling cascades. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 value of 5.6 pM, and it suppresses IL-23-induced interferon-gamma production in natural killer cells with an IC50 value of 18.4 pM. Icotrokinra further demonstrates anti-inflammatory effects in a rat TNBS-induced colitis model, making it a compound of interest in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease.

Produkteigenschaften

• Molekulargewicht: 1898.17
• Reinheit: 99.93%
• CAS Nummer: [2763602-16-8]
• Formel: C90H120N20O22S2
• Target-Kategorie: IL Receptor

Bilder

T89073