HM43239, CAS [[2294874-49-8]]

Produktübersicht

• Artikelname: HM43239, CAS [[2294874-49-8]]
• Artikelnummer: TGM-T9428
• Hersteller Artikelnummer: T9428
• Alternativnummer: TGM-T9428-1MLX10MM(INDMSO),TGM-T9428-1MG,TGM-T9428-5MG,TGM-T9428-10MG,TGM-T9428-25MG,TGM-T9428-50MG,TGM-T9428-100MG,TGM-T9428-200MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: Tuspetinib

Produktbeschreibung

HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates downstream p-STAT5 and p-ERK. HM43239 also demonstrated inhibition of SYK, JAK1/2 and TAK1. HM43239 inhibits the proliferation and induces the apoptosis of leukemic cells [1] [2] [3].

Produkteigenschaften

• Molekulargewicht: 501.07
• Reinheit: 98.56%
• CAS Nummer: [2294874-49-8]
• Formel: C29H33ClN6
• Target-Kategorie: FLT|||Apoptosis

Bilder

T9428