Syk Inhibitor II hydrochloride, CAS [[2490508-82-0]]

Produktübersicht

• Artikelname: Syk Inhibitor II hydrochloride, CAS [[2490508-82-0]]
• Artikelnummer: TGM-T9543
• Hersteller Artikelnummer: T9543
• Alternativnummer: TGM-T9543-1MLX10MM(INDMSO),TGM-T9543-1MG,TGM-T9543-5MG,TGM-T9543-10MG,TGM-T9543-25MG,TGM-T9543-50MG,TGM-T9543-100MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (13)-beta-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice with sepsis. Syk inhibition downregulated several inflammatory pathways in FcgRIIb-/- macrophages activated with BG + LPS suggesting the potential anti-inflammatory impact of Syk inhibitors in lupus. Indeed, administration of a Syk inhibitor prior to cecal ligation and puncture (CLP) sepsis in FcgRIIb-/- mice reduced baseline lupus-induced proinflammatory cytokines and attenuated sepsis severity as evaluated by mortality, organ injury, serum LPS, and post-sepsis serum cytokines.

Produkteigenschaften

• Molekulargewicht: 376.77
• Reinheit: 0.9905
• CAS Nummer: [2490508-82-0]
• Formel: C14H16ClF3N6O
• Target-Kategorie: 5-HT Receptor|||Syk|||Others

Bilder

T9543