SAR-446523 is a humanized IgG1 monoclonal antibody inhibitor targeting GPRC5D. It significantly induces antibody-dependent cell-mediated cytotoxicity (ADCC). SAR-446523 exhibits potent antitumor activity by enhancing survival rates in mice in the NOG huIL15 transgenic mouse model, which carries multiple myeloma (MM) cells. This compound is applicable for research into multiple myeloma (MM).
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