MEDI4212 is a humanized IgG1lambda monoclonal antibody inhibitor targeting IgE. It effectively inhibits human IgE-mediated functional responses, such as calcium signaling, beta-hexosaminidase release, and phagocytosis, through its receptor FcepsilonRI. MEDI4212 prevents IgE from binding to CD23 with an IC50 of 8 nM and can be utilized in severe asthma research.
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