REGN7999 is a monoclonal antibody that inhibits TMPRSS6. By suppressing TMPRSS6 activity, REGN7999 prevents HJV cleavage, enhancing BMP6-HJV signaling and increasing serum hepcidin levels. This inhibition aids in alleviating iron overload and impaired erythropoiesis in beta-thalassemia mouse models. REGN7999 is applicable for research in beta-thalassemia.
Target-Kategorie:
Serine Protease
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