DSPE-PEG2000-iRGD is a functionalized lipid composed of DSPE, PEG chain and iRGD peptide targeting alphav- integrin. IRGD peptide binds to alphav- integrin and undergoes proteolysis in tumor microenvironment to generate CendR motif (CRGDK/R), which then interacts with neuropilin-1, thus endowing it with tumor targeting and tissue penetration ability, and is often used in the study of active molecule delivery.
Target-Kategorie:
Integrin|||Liposome|||Complement System
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