Gigantol is a novel inhibitor of the Wnt/beta-catenin pathway. It inhibits Wnt/beta-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic beta-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows the protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-kappaB signaling pathway.Gigantol also shows alpha-glucosidase inhibitory activity.
Molekulargewicht:
274.31
Reinheit:
98.00%
CAS Nummer:
[67884-30-4]
Formel:
C16H18O4
Target-Kategorie:
Glucosidase|||Wnt/beta-catenin
TL0008
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